MolNFT v1 · #165026 · protein
Crystal structure of arabidopsis thaliana NAA60 in complex with acetyl-CoA
6TH0 · Acyl-CoA N-acyltransferases (nat) superfamily protein: “Crystal structure of arabidopsis thaliana NAA60 in complex with acetyl-CoA”. X-ray diffraction, 1 ligand (ACO), 4 pockets (best druggability 0.66). MolNFT v1 #165026 on…
- PDB
- 6TH0
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acyl-CoA N-acyltransferases (nat) superfamily protein
- UniProt
- Q6NLS5
- Ligands
- ACO
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acyl-CoA N-acyltransferases (nat) superfamily protein | protein | 176 | 32% helix, 38% strand | Q6NLS5 |
| B | Acyl-CoA N-acyltransferases (nat) superfamily protein | protein | 172 | 35% helix, 35% strand | Q6NLS5 |
Ligands and binding sites
- ACO · Acetyl coenzyme *A · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.66 | 0.81 | 34 | ACO |
| 2 | 437 | 0.65 | 0.77 | 38 | ACO |
| 3 | 94 | 0.40 | 0.77 | 12 | empty |
| 4 | 80 | 0.38 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1104 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6TH0 · Crystal structure of Arabidopsis thaliana NAA60 in complex with acetyl-CoA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6NLS5
- Elsewhere: RCSB PDB 6TH0 · PDBe 6TH0 · UniProt Q6NLS5
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