MolNFT v1 · #164868 · protein
Crystal structure of MMS19-CIAO1-CIAO2B cia targeting complex
6TC0 · Probable cytosolic iron-sulfur protein assembly protein…: “Crystal structure of MMS19-CIAO1-CIAO2B cia targeting complex”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #164868 on GenesisL1: 3D structure, binding…
- PDB
- 6TC0
- Type
- protein
- Length
- 2,963 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable cytosolic iron-sulfur protein assembly protein CIAO1; MIP18 family protein…
- UniProt
- Q7K1Y4, Q9VTC4, Q9D071
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 62% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Probable cytosolic iron-sulfur protein assembly protein CIAO1 | protein | 336 | 0% helix, 52% strand | Q7K1Y4 |
| B, E | MIP18 family protein galla-2 | protein | 154 | 41% helix, 12% strand | Q9VTC4 |
| C | MMS19 nucleotide excision repair protein homolog | protein | 994 | 74% helix, 0% strand | Q9D071 |
| F | MMS19 nucleotide excision repair protein homolog | protein | 989 | 74% helix, 0% strand | Q9D071 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.81 | 0.84 | 102 | empty |
| 2 | 473 | 0.79 | 0.87 | 37 | empty |
| 3 | 843 | 0.79 | 0.82 | 60 | empty |
| 4 | 479 | 0.78 | 0.86 | 37 | empty |
| 5 | 1019 | 0.78 | 0.80 | 71 | empty |
Interfaces
12 interfaces between chains.
- C–F · 3214 Ų buried · 34 hydrogen bonds · protein-protein
- B–E · 1674 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 908 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 893 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 889 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6TC0 · Crystal structure of MMS19-CIAO1-CIAO2B CIA targeting complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q7K1Y4 · AlphaFold monomer V2.0 prediction for probable cytosolic iron-sulfur protein assembly… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9VTC4 · AlphaFold monomer V2.0 prediction for MIP18 family protein galla-2 (Q9VTC4) · a predicted model of the same protein · chain B against A, TM-score 0.89
- Q9D071 · AlphaFold monomer V2.0 prediction for MMS19 nucleotide excision repair protein homolog… · a predicted model of the same protein · chain C against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7K1Y4
- Every structure of UniProt Q9VTC4
- Every structure of UniProt Q9D071
- Elsewhere: RCSB PDB 6TC0 · PDBe 6TC0 · UniProt Q7K1Y4 · UniProt Q9VTC4 · UniProt Q9D071
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