MolNFT v1 · #164848 · protein
Crystal structure of the SVS_A2 protein from ancestral sequence reconstruction at 2.30 a resolution
6TBD · Design protein SVS_A2: “Crystal structure of the SVS_A2 protein from ancestral sequence reconstruction at 2.30 a resolution”. X-ray diffraction, 8 pockets (best druggability 0.82). MolNFT v1 #164848 on GenesisL1: 3D structure…
- PDB
- 6TBD
- Type
- protein
- Length
- 643 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Design protein SVS_A2
- EC
- 4.2.3.158
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Design protein SVS_A2 (EC 4.2.3.158) | protein | 327 | 69% helix, 1% strand | — |
| B | Design protein SVS_A2 (EC 4.2.3.158) | protein | 316 | 69% helix, 1% strand | — |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.82 | 0.97 | 49 | empty |
| 2 | 106 | 0.76 | 0.96 | 29 | empty |
| 3 | 363 | 0.70 | 0.83 | 40 | empty |
| 4 | 376 | 0.66 | 0.80 | 48 | empty |
| 5 | 86 | 0.58 | 0.87 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1875 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 6TBD · Crystal structure of the SVS_A2 protein from ancestral sequence reconstruction at 2.30 A… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6TBD · PDBe 6TBD
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