MolNFT v1 · #164828 · protein

Structure of the DARC2 capsid

6TAQ · Activity-regulated cytoskeleton associated protein 2: “Structure of the DARC2 capsid”. Electron microscopy, 11 pockets (best druggability 0.62). MolNFT v1 #164828 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TAQ
Type: protein
Length: 656 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Activity-regulated cytoskeleton associated protein 2
UniProt: Q7JV70
Pockets: 11 · best druggability 0.62

Structure

electron microscopy · 1 distinct chain · 53% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Activity-regulated cytoskeleton associated protein 2	protein	164	53% helix, 0% strand	Q7JV70

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.62	0.78	52	empty
2	70	0.58	0.89	19	empty
3	171	0.58	0.81	26	empty
4	286	0.56	0.77	37	empty
5	171	0.48	0.77	21	empty

Interfaces

3 interfaces between chains.

B–C · 1048 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 935 Å² buried · 1 hydrogen bond · protein-protein
B–A · 855 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6TAQ · Structure of the dArc2 capsid · the same entry in another collection · chain D against D, TM-score 1.00
Q7JV70 · AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7JV70
Elsewhere: RCSB PDB 6TAQ · PDBe 6TAQ · UniProt Q7JV70

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