MolNFT v1 · #164744 · protein

Mexb structure solved by cryo-EM in nanodisc in absence of its protein partners

6T7S · Efflux pump membrane transporter: “Mexb structure solved by cryo-EM in nanodisc in absence of its protein partners”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #164744 on GenesisL1: 3D structure, binding…

PDB: 6T7S
Type: protein
Length: 3,090 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Efflux pump membrane transporter
UniProt: A0A069Q9M6
Pockets: 20 · best druggability 0.89

Structure

electron microscopy · 1 distinct chain · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
J, K, L	Efflux pump membrane transporter	protein	1030	42% helix, 16% strand	A0A069Q9M6

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1190	0.89	0.91	130	empty
2	711	0.87	0.91	113	empty
3	686	0.87	0.91	96	empty
4	599	0.85	0.90	77	empty
5	573	0.84	0.89	80	empty

Interfaces

3 interfaces between chains.

J–L · 3422 Å² buried · 37 hydrogen bonds · protein-protein
K–L · 3291 Å² buried · 27 hydrogen bonds · protein-protein
J–K · 3092 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

6T7S · MexB structure solved by cryo-EM in nanodisc in absence of its protein partners · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A069Q9M6
Elsewhere: RCSB PDB 6T7S · PDBe 6T7S · UniProt A0A069Q9M6

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