MolNFT v1 · #164628 · protein
Psychrophilic aromatic amino acids aminotransferase from psychrobacter sp. B6 cocrystalized with substrate analog - malic acid
6T3V: “Psychrophilic aromatic amino acids aminotransferase from psychrobacter sp. B6 cocrystalized with substrate…”. X-ray diffraction, 2 ligands (PLP, LMR), 5 pockets (best druggability 0.65). MolNFT v1 #164628 on GenesisL1: 3D structure…
- PDB
- 6T3V
- Type
- protein
- Length
- 398 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aminotransferase
- EC
- 2.6.1.-
- UniProt
- C7E5X4
- Ligands
- PLP, LMR
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aminotransferase (EC 2.6.1.-) | protein | 398 | 46% helix, 13% strand | C7E5X4 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
- LMR · (2S)-2-hydroxybutanedioic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.65 | 0.83 | 39 | PLP, LMR |
| 2 | 123 | 0.43 | 0.76 | 22 | empty |
| 3 | 75 | 0.38 | 0.78 | 16 | empty |
| 4 | 56 | 0.30 | 0.75 | 14 | empty |
| 5 | 52 | 0.23 | 0.72 | 19 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 6T3V · Psychrophilic aromatic amino acids aminotransferase from Psychrobacter sp. B6… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7E5X4
- Elsewhere: RCSB PDB 6T3V · PDBe 6T3V · UniProt C7E5X4
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