MolNFT v1 · #164581 · protein
Multicomponent peptide stapling as a diversity-driven tool for the development of inhibitors of protein-protein interactions
6T2E · E3 ubiquitin-protein ligase MDM2: “Multicomponent peptide stapling as a diversity-driven tool for the development of inhibitors of…”. X-ray diffraction. MolNFT v1 #164581 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6T2E
- Type
- protein
- Length
- 99 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase MDM2; Stapled peptide GAR300-gm
- EC
- 2.3.2.27
- UniProt
- Q00987
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase MDM2 (EC 2.3.2.27) | protein | 85 | 47% helix, 18% strand | Q00987 |
| B | Stapled peptide GAR300-gm | protein | 14 | 71% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 730 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6T2E · Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00987
- Elsewhere: RCSB PDB 6T2E · PDBe 6T2E · UniProt Q00987
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