MolNFT v1 · #164431 · protein
Crystal structure of P212121 apo form of crte
6SXN · Geranylgeranyl pyrophosphate synthase: “Crystal structure of P212121 apo form of crte”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #164431 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6SXN
- Type
- protein
- Length
- 1,563 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Geranylgeranyl pyrophosphate synthase
- UniProt
- B1XJV9
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 6 distinct chains · 74% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Geranylgeranyl pyrophosphate synthase | protein | 267 | 73% helix, 1% strand | B1XJV9 |
| B | Geranylgeranyl pyrophosphate synthase | protein | 259 | 74% helix, 2% strand | B1XJV9 |
| C | Geranylgeranyl pyrophosphate synthase | protein | 258 | 74% helix, 2% strand | B1XJV9 |
| D | Geranylgeranyl pyrophosphate synthase | protein | 267 | 71% helix, 1% strand | B1XJV9 |
| E | Geranylgeranyl pyrophosphate synthase | protein | 259 | 75% helix, 2% strand | B1XJV9 |
| F | Geranylgeranyl pyrophosphate synthase | protein | 253 | 76% helix, 2% strand | B1XJV9 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 433 | 0.78 | 0.86 | 62 | empty |
| 2 | 827 | 0.78 | 0.81 | 69 | empty |
| 3 | 858 | 0.77 | 0.80 | 100 | empty |
| 4 | 634 | 0.73 | 0.80 | 71 | empty |
| 5 | 454 | 0.73 | 0.82 | 63 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1924 Ų buried · 6 hydrogen bonds · protein-protein
- C–E · 1901 Ų buried · 8 hydrogen bonds · protein-protein
- D–F · 1858 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 502 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 475 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6SXN · Crystal structure of P212121 apo form of CrtE · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1XJV9
- Elsewhere: RCSB PDB 6SXN · PDBe 6SXN · UniProt B1XJV9
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