MolNFT v1 · #164392 · protein

Crystal structure of the NS1 (H7N1) RNA-binding domain

6SW8 · Non-structural protein 1: “Crystal structure of the NS1 (H7N1) RNA-binding domain”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #164392 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6SW8
Type: protein
Length: 146 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 1
UniProt: Q1PST0
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Non-structural protein 1	protein	73	82% helix, 0% strand	Q1PST0

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	171	0.63	0.85	21	PEG
2	51	0.36	0.79	11	EDO
3	50	0.28	0.74	9	PEG

Interfaces

1 interface between chains.

A–B · 1289 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6SW8 · Crystal structure of the NS1 (H7N1) RNA-binding domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1PST0
Elsewhere: RCSB PDB 6SW8 · PDBe 6SW8 · UniProt Q1PST0

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