MolNFT v1 · #164351 · protein
Human prion protein (prp) fragment 119-231 (G127V V129 variant) complexed to icsm 18 (anti-prp therapeutic antibody) Fab fragment
6SUZ · Major prion protein: “Human prion protein (prp) fragment 119-231 (G127V V129 variant) complexed to icsm 18 (anti-prp therapeutic…”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.59). MolNFT v1 #164351 on…
- PDB
- 6SUZ
- Type
- protein
- Length
- 525 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major prion protein; Icsm 18-anti-prp therapeutic Fab heavy chain; Icsm 18-anti-prp…
- UniProt
- P04156
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major prion protein | protein | 99 | 60% helix, 4% strand | P04156 |
| H | Icsm 18-anti-prp therapeutic Fab heavy chain | protein | 215 | 7% helix, 54% strand | — |
| L | Icsm 18-anti-prp therapeutic Fab light chain | protein | 211 | 6% helix, 54% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.59 | 0.74 | 60 | empty |
| 2 | 162 | 0.46 | 0.76 | 27 | empty |
| 3 | 66 | 0.32 | 0.75 | 15 | empty |
| 4 | 61 | 0.30 | 0.75 | 15 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1630 Ų buried · 14 hydrogen bonds · protein-protein
- A–H · 581 Ų buried · 11 hydrogen bonds · protein-protein
- A–L · 384 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6SUZ · Human prion protein (PrP) fragment 119-231 (G127V V129 variant) complexed to ICSM 18… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04156
- Elsewhere: RCSB PDB 6SUZ · PDBe 6SUZ · UniProt P04156
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.