MolNFT v1 · #164275 · protein
Crystal structure of human microsomal glutathione S-transferase 2 at 3.8 ångströms resolution
6SSR: “Crystal structure of human microsomal glutathione S-transferase 2 at 3.8 ångströms resolution”. X-ray diffraction, 6 pockets (best druggability 0.86). MolNFT v1 #164275 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6SSR
- Type
- protein
- Length
- 401 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microsomal glutathione S-transferase 2
- EC
- 2.5.1.18
- UniProt
- Q99735
- Pockets
- 6 · best druggability 0.86
Structure
x-ray diffraction · 3 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Microsomal glutathione S-transferase 2 (EC 2.5.1.18) | protein | 135 | 82% helix, 0% strand | Q99735 |
| B | Microsomal glutathione S-transferase 2 (EC 2.5.1.18) | protein | 136 | 84% helix, 0% strand | Q99735 |
| C | Microsomal glutathione S-transferase 2 (EC 2.5.1.18) | protein | 130 | 86% helix, 0% strand | Q99735 |
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 242 | 0.86 | 0.97 | 23 | empty |
| 2 | 50 | 0.66 | 0.96 | 12 | empty |
| 3 | 230 | 0.64 | 0.82 | 29 | empty |
| 4 | 144 | 0.61 | 0.85 | 24 | empty |
| 5 | 181 | 0.61 | 0.83 | 33 | empty |
Interfaces
3 interfaces between chains.
- B–C · 976 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 947 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 943 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6SSR · Crystal structure of Human Microsomal Glutathione S-Transferase 2 at 3.8 Angstroms… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99735 · AlphaFold monomer V2.0 prediction for microsomal glutathione S-transferase 2 (Q99735) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99735
- Elsewhere: RCSB PDB 6SSR · PDBe 6SSR · UniProt Q99735
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.