MolNFT v1 · #16427 · protein

The closed state structure of M2 protein H+ channel by solid state NMR spectroscopy

1NYJ · Matrix protein M2: “The closed state structure of M2 protein H+ channel by solid state NMR spectroscopy”. Solid-state nmr, 1 pocket (best druggability 0.76). MolNFT v1 #16427 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1NYJ
Type: protein
Length: 100 residues
Chains: 4
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Matrix protein M2
UniProt: P35938
Pockets: 1 · best druggability 0.76

Structure

solid-state nmr · 1 distinct chain · 92% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Matrix protein M2	protein	25	92% helix, 0% strand	P35938

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	398	0.76	0.85	39	empty

Interfaces

4 interfaces between chains.

B–C · 342 Å² buried · 1 hydrogen bond · protein-protein
C–D · 338 Å² buried · 1 hydrogen bond · protein-protein
A–D · 337 Å² buried · 1 hydrogen bond · protein-protein
A–B · 335 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1NYJ · The closed state structure of M2 protein H+ channel by solid state NMR spectroscopy · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35938
Elsewhere: RCSB PDB 1NYJ · PDBe 1NYJ · UniProt P35938

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