MolNFT v1 · #164246 · protein
Crystal structure of human SHIP2 catalytic domain
6SRR · Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2: “Crystal structure of human SHIP2 catalytic domain”. X-ray diffraction, 7 pockets (best druggability 0.53). MolNFT v1 #164246 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6SRR
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- EC
- 3.1.3.86
- UniProt
- O15357
- Pockets
- 7 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) | protein | 311 | 21% helix, 33% strand | O15357 |
| A | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) | protein | 289 | 21% helix, 35% strand | O15357 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.53 | 0.84 | 18 | empty |
| 2 | 77 | 0.53 | 0.85 | 19 | empty |
| 3 | 88 | 0.48 | 0.82 | 20 | empty |
| 4 | 226 | 0.44 | 0.73 | 39 | empty |
| 5 | 72 | 0.33 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- B–A · 511 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15357
- Elsewhere: RCSB PDB 6SRR · PDBe 6SRR · UniProt O15357
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