MolNFT v1 · #164061 · protein

Mutant immunoglobulin light chain causing amyloidosis (pat-1)

6SM2: “Mutant immunoglobulin light chain causing amyloidosis (pat-1)”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #164061 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6SM2
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pat-1
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pat-1	protein	109	7% helix, 46% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.30	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 723 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6SM2 · Mutant immunoglobulin light chain causing amyloidosis (Pat-1) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6SM2 · PDBe 6SM2

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