MolNFT v1 · #164053 · protein
Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,11)
6SLU · Gag protein: “Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,11)”. Electron microscopy, 20 pockets (best druggability 0.74). MolNFT v1 #164053 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6SLU
- Type
- protein
- Length
- 1,320 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag protein
- UniProt
- Q71B32
- Pockets
- 20 · best druggability 0.74
Structure
electron microscopy · 1 distinct chain · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Gag protein | protein | 220 | 59% helix, 3% strand | Q71B32 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1011 | 0.74 | 0.77 | 102 | empty |
| 2 | 1070 | 0.74 | 0.77 | 103 | empty |
| 3 | 471 | 0.73 | 0.82 | 69 | empty |
| 4 | 124 | 0.71 | 0.91 | 25 | empty |
| 5 | 584 | 0.71 | 0.79 | 59 | empty |
Interfaces
7 interfaces between chains.
- A–F · 1249 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 1182 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1178 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1151 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 1080 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6SLU · Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,11) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71B32
- Elsewhere: RCSB PDB 6SLU · PDBe 6SLU · UniProt Q71B32
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