MolNFT v1 · #163982 · protein

Methyltransferase mtga from desulfitobacterium hafniense

6SJK · Tetrahydromethanopterin S-methyltransferase: “Methyltransferase mtga from desulfitobacterium hafniense”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #163982 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6SJK
Type: protein
Length: 608 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetrahydromethanopterin S-methyltransferase
EC: 2.1.1.86
UniProt: B8FUR2
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tetrahydromethanopterin S-methyltransferase (EC 2.1.1.86)	protein	304	46% helix, 19% strand	B8FUR2

Ligands and binding sites

GOL · Glycerol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	371	0.64	0.79	34	empty
2	431	0.64	0.78	46	empty
3	413	0.62	0.77	53	empty
4	108	0.43	0.78	16	empty
5	85	0.36	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1938 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6SJK · Methyltransferase MtgA from Desulfitobacterium hafniense · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B8FUR2
Elsewhere: RCSB PDB 6SJK · PDBe 6SJK · UniProt B8FUR2

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