MolNFT v1 · #163914 · protein

An inactive (D136A and D137A) variant of alpha-1,6-mannanase, GH76A of salegentibacter sp. HEL1_6 in complex with alpha-1,6-mannotetrose

6SHM · Mutant alpha-1,6-mannanase GH76A: “An inactive (D136A and D137A) variant of alpha-1,6-mannanase, GH76A of salegentibacter sp. HEL1_6 in complex…”. X-ray diffraction, 1 ligand (MAN), 2 pockets (best druggability 0.53). MolNFT v1…

PDB: 6SHM
Type: protein
Length: 339 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mutant alpha-1,6-mannanase GH76A
Ligands: MAN
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mutant alpha-1,6-mannanase GH76A	protein	339	63% helix, 9% strand	—

Ligands and binding sites

MAN · alpha-D-mannopyranose · sugar · 4 copies · chains A
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.53	0.78	28	empty
2	137	0.48	0.78	21	MAN

Compared structures

6SHM · An inactive (D136A and D137A) variant of alpha-1,6-mannanase, GH76A of Salegentibacter… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6SHM · PDBe 6SHM

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