MolNFT v1 · #16390 · protein
X-ray structure: northeast structural genomics consortium target TT87
1NXH · MTH396 protein: “X-ray structure: northeast structural genomics consortium target TT87”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #16390 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1NXH
- Type
- protein
- Length
- 242 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MTH396 protein
- UniProt
- O26496
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MTH396 protein | protein | 124 | 77% helix, 0% strand | O26496 |
| B | MTH396 protein | protein | 118 | 77% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.61 | 0.79 | 36 | empty |
| 2 | 133 | 0.50 | 0.79 | 18 | empty |
| 3 | 58 | 0.37 | 0.79 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1888 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 1NXH · X-ray structure: northeast structural genomics consortium target TT87 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26496
- Elsewhere: RCSB PDB 1NXH · PDBe 1NXH · UniProt O26496
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