MolNFT v1 · #163863 · protein

Mouse interleukin-12 subunit beta - P80 homodimer in space group I41

6SFF: “Mouse interleukin-12 subunit beta - P80 homodimer in space group I41”. X-ray diffraction, 4 ligands (MAN, NAG, BMA), 1 pocket (best druggability 0.50). MolNFT v1 #163863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6SFF
Type: protein
Length: 295 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-12 subunit beta
UniProt: P43432
Ligands: MAN, NAG, BMA, CL
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-12 subunit beta	protein	295	2% helix, 53% strand	P43432

Ligands and binding sites

MAN · alpha-D-mannopyranose · sugar · 3 copies · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
BMA · beta-D-mannopyranose · sugar · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.50	0.79	23	empty

Modifications

Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

6SFF · mouse Interleukin-12 subunit beta - p80 homodimer in space group I41 · the same entry in another collection · chain A against A, TM-score 1.00
P43432 · AlphaFold monomer V2.0 prediction for interleukin-12 subunit beta (P43432) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43432
Elsewhere: RCSB PDB 6SFF · PDBe 6SFF · UniProt P43432

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