MolNFT v1 · #163770 · protein
Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex
6SCT · Clathrin heavy chain: “Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #163770 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6SCT
- Type
- protein
- Length
- 4,947 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Clathrin heavy chain; Clathrin light chain
- UniProt
- C0MHR2, F1S398
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F, K | Clathrin heavy chain | protein | 379 | 71% helix, 0% strand | C0MHR2 |
| B, G, L | Clathrin heavy chain | protein | 666 | 66% helix, 0% strand | C0MHR2 |
| C, H, M | Clathrin heavy chain | protein | 441 | 63% helix, 0% strand | C0MHR2 |
| D, I, N | Clathrin light chain | protein | 104 | 72% helix, 0% strand | F1S398 |
| E, J, O | Clathrin light chain | protein | 59 | 90% helix, 0% strand | F1S398 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 559 | 0.82 | 0.87 | 55 | empty |
| 2 | 736 | 0.78 | 0.82 | 77 | empty |
| 3 | 724 | 0.77 | 0.82 | 88 | empty |
| 4 | 982 | 0.77 | 0.79 | 75 | empty |
| 5 | 1003 | 0.76 | 0.79 | 94 | empty |
Interfaces
33 interfaces between chains.
- A–D · 2180 Ų buried · 11 hydrogen bonds · protein-protein
- F–I · 2175 Ų buried · 10 hydrogen bonds · protein-protein
- K–N · 2168 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1636 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 1605 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6SCT · Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0MHR2
- Every structure of UniProt F1S398
- Elsewhere: RCSB PDB 6SCT · PDBe 6SCT · UniProt C0MHR2 · UniProt F1S398
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