MolNFT v1 · #163756 · protein + RNA

A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate

6SCF · Uncharacterized protein: “A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate”. X-ray diffraction, 12 pockets (best druggability 0.82). MolNFT v1 #163756 on GenesisL1: 3D structure…

PDB: 6SCF
Type: protein + RNA
Length: 913 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein; Cyclic oligoadenylate
UniProt: Q8QL27
Pockets: 12 · best druggability 0.82

Structure

x-ray diffraction · 6 distinct chains · 28% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Uncharacterized protein	protein	113	27% helix, 26% strand	Q8QL27
C, D, G	Uncharacterized protein	protein	112	28% helix, 27% strand	Q8QL27
E	Uncharacterized protein	protein	112	28% helix, 26% strand	Q8QL27
F	Uncharacterized protein	protein	114	27% helix, 25% strand	Q8QL27
H	Uncharacterized protein	protein	109	28% helix, 25% strand	Q8QL27
K, I, L, M	Cyclic oligoadenylate	rna	4	—	—

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	727	0.82	0.86	79	empty
2	103	0.77	0.98	28	empty
3	100	0.76	0.97	27	empty
4	90	0.76	0.98	27	empty
5	366	0.69	0.82	42	empty

Interfaces

22 interfaces between chains.

B–G · 1541 Å² buried · 33 hydrogen bonds · protein-protein
C–E · 1530 Å² buried · 31 hydrogen bonds · protein-protein
D–F · 1525 Å² buried · 32 hydrogen bonds · protein-protein
A–F · 666 Å² buried · 12 hydrogen bonds · protein-protein
E–L · 624 Å² buried · 22 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

6SCF · A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic… · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8QL27
Elsewhere: RCSB PDB 6SCF · PDBe 6SCF · UniProt Q8QL27

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