MolNFT v1 · #163636 · protein

Crystal structure of the rab-binding domain of FIP2

6S8X · RAB11 family-interacting protein 2: “Crystal structure of the rab-binding domain of FIP2”. X-ray diffraction, 4 pockets (best druggability 0.33). MolNFT v1 #163636 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6S8X
Type: protein
Length: 201 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAB11 family-interacting protein 2
UniProt: Q7L804
Pockets: 4 · best druggability 0.33

Structure

x-ray diffraction · 4 distinct chains · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAB11 family-interacting protein 2	protein	53	92% helix, 0% strand	Q7L804
B	RAB11 family-interacting protein 2	protein	52	94% helix, 0% strand	Q7L804
D	RAB11 family-interacting protein 2	protein	49	86% helix, 0% strand	Q7L804
E	RAB11 family-interacting protein 2	protein	47	89% helix, 0% strand	Q7L804

Ligands and binding sites

HEZ · Hexane-1,6-diol · additive · chains E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.33	0.74	12	empty
2	53	0.27	0.74	10	empty
3	51	0.26	0.73	10	empty
4	56	0.25	0.73	12	empty

Interfaces

2 interfaces between chains.

B–E · 702 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 662 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6S8X · Crystal structure of the Rab-binding domain of FIP2 · the same entry in another collection · chain E against E, TM-score 1.00
Q7L804 · AlphaFold monomer V2.0 prediction for RAB11 family-interacting protein 2 (Q7L804) · a predicted model of the same protein · chain E against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7L804
Elsewhere: RCSB PDB 6S8X · PDBe 6S8X · UniProt Q7L804

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