MolNFT v1 · #163466 · protein

Adhesin P140 from mycoplasma genitalium

6S3U: “Adhesin P140 from mycoplasma genitalium”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #163466 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6S3U
Type: protein
Length: 7,622 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adhesin P1
UniProt: P20796
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 6 distinct chains · 20% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adhesin P1	protein	1278	20% helix, 21% strand	P20796
B	Adhesin P1	protein	1275	20% helix, 21% strand	P20796
C	Adhesin P1	protein	1274	20% helix, 21% strand	P20796
D	Adhesin P1	protein	1271	20% helix, 21% strand	P20796
E	Adhesin P1	protein	1262	20% helix, 21% strand	P20796
F	Adhesin P1	protein	1262	20% helix, 21% strand	P20796

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1169	0.86	0.86	123	empty
2	1110	0.85	0.85	104	empty
3	622	0.84	0.88	70	empty
4	228	0.82	0.95	58	empty
5	199	0.82	0.96	42	empty

Interfaces

8 interfaces between chains.

A–B · 2731 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 2650 Å² buried · 26 hydrogen bonds · protein-protein
E–F · 1986 Å² buried · 20 hydrogen bonds · protein-protein
A–D · 355 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 313 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6S3U · Adhesin P140 from Mycoplasma Genitalium · the same entry in another collection · chain F against F, TM-score 1.00
P20796 · AlphaFold monomer V2.0 prediction for adhesin P1 (P20796) · a predicted model of the same protein · chain E against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20796
Elsewhere: RCSB PDB 6S3U · PDBe 6S3U · UniProt P20796

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