MolNFT v1 · #163422 · protein
Fmdv 3D polymerase crystallized in presence of (F)URIDYLYLATED vpg peptide
6S2L · Genome polyprotein: “Fmdv 3D polymerase crystallized in presence of (F)URIDYLYLATED vpg peptide”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #163422 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6S2L
- Type
- protein
- Length
- 476 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03311
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 476 | 42% helix, 19% strand | P03311 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.72 | 0.82 | 43 | GOL |
| 2 | 757 | 0.68 | 0.75 | 55 | empty |
Compared structures
- 6S2L · FMDV 3D polymerase crystallized in presence of (F)uridylylated VPg peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03311
- Elsewhere: RCSB PDB 6S2L · PDBe 6S2L · UniProt P03311
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