MolNFT v1 · #163410 · protein
Structure of fission yeast MIS16-MIS19 complex
6S29 · Histone acetyltransferase type B subunit 2: “Structure of fission yeast MIS16-MIS19 complex”. X-ray diffraction, 1 ligand (BR), 9 pockets (best druggability 0.77). MolNFT v1 #163410 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6S29
- Type
- protein
- Length
- 894 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase type B subunit 2; Cenp-a recruiting complex protein MIS19
- UniProt
- O94244, O42995
- Ligands
- BR
- Pockets
- 9 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase type B subunit 2 | protein | 393 | 10% helix, 44% strand | O94244 |
| B | Cenp-a recruiting complex protein MIS19 | protein | 53 | 51% helix, 11% strand | O42995 |
| C | Histone acetyltransferase type B subunit 2 | protein | 394 | 10% helix, 43% strand | O94244 |
| D | Cenp-a recruiting complex protein MIS19 | protein | 54 | 48% helix, 13% strand | O42995 |
Ligands and binding sites
- BR · Bromide ion · ion · 6 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 657 | 0.77 | 0.83 | 57 | BR |
| 2 | 627 | 0.77 | 0.83 | 49 | BR |
| 3 | 282 | 0.52 | 0.75 | 42 | empty |
| 4 | 143 | 0.40 | 0.74 | 23 | empty |
| 5 | 132 | 0.39 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1749 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1723 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 548 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6S29 · Structure of fission yeast Mis16-Mis19 complex · the same entry in another collection · chain D against D, TM-score 1.00
- O94244 · AlphaFold monomer V2.0 prediction for histone acetyltransferase type B subunit 2 (O94244) · a predicted model of the same protein · chain C against A, TM-score 0.96
- O42995 · AlphaFold monomer V2.0 prediction for cenp-a recruiting complex protein MIS19 (O42995) · a predicted model of the same protein · chain D against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94244
- Every structure of UniProt O42995
- Elsewhere: RCSB PDB 6S29 · PDBe 6S29 · UniProt O94244 · UniProt O42995
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