MolNFT v1 · #163398 · protein

Crystal structure of dimeric M-pmv protease D26N mutant

6S1W · Gag-pro-pol polyprotein: “Crystal structure of dimeric M-pmv protease D26N mutant”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #163398 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6S1W
Type: protein
Length: 205 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gag-pro-pol polyprotein
EC: 3.6.1.23, 3.4.23.-, 2.7.7.49, 2.7.7.7, 3.1.26.4, 2.7.7.-, 3.1.-.-
UniProt: P07572
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Gag-pro-pol polyprotein (EC 3.6.1.23, 3.4.23.-, 2.7.7.49, 2.7.7.7, 3.1.26.4, 2.7.7.-, 3.1.-.-)	protein	108	11% helix, 39% strand	P07572
A	Gag-pro-pol polyprotein (EC 3.6.1.23, 3.4.23.-, 2.7.7.49, 2.7.7.7, 3.1.26.4, 2.7.7.-, 3.1.-.-)	protein	97	9% helix, 42% strand	P07572

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	191	0.50	0.76	29	empty

Interfaces

1 interface between chains.

B–A · 1484 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

6S1W · Crystal structure of dimeric M-PMV protease D26N mutant · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07572
Elsewhere: RCSB PDB 6S1W · PDBe 6S1W · UniProt P07572

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