MolNFT v1 · #163393 · protein
Structure of fission yeast MIS16 bound to histone H4
6S1R · Histone acetyltransferase type B subunit 2: “Structure of fission yeast MIS16 bound to histone H4”. X-ray diffraction, 4 pockets (best druggability 0.77). MolNFT v1 #163393 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6S1R
- Type
- protein
- Length
- 406 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase type B subunit 2; Histone H4
- UniProt
- O94244, P09322
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase type B subunit 2 | protein | 391 | 12% helix, 44% strand | O94244 |
| B | Histone H4 | protein | 15 | 60% helix, 0% strand | P09322 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.77 | 0.83 | 47 | empty |
| 2 | 65 | 0.31 | 0.76 | 12 | empty |
| 3 | 52 | 0.28 | 0.75 | 15 | empty |
| 4 | 51 | 0.27 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 782 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6S1R · Structure of fission yeast Mis16 bound to histone H4 · the same entry in another collection · chain B against B, TM-score 1.00
- O94244 · AlphaFold monomer V2.0 prediction for histone acetyltransferase type B subunit 2 (O94244) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P09322 · AlphaFold monomer V2.0 prediction for histone H4 (P09322) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94244
- Every structure of UniProt P09322
- Elsewhere: RCSB PDB 6S1R · PDBe 6S1R · UniProt O94244 · UniProt P09322
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.