MolNFT v1 · #163333 · protein
Structure of S-MGM1 decorating the inner surface of tubulated lipid membranes
6RZV · Putative mitochondrial dynamin protein: “Structure of S-MGM1 decorating the inner surface of tubulated lipid membranes”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #163333 on GenesisL1: 3D structure, binding…
- PDB
- 6RZV
- Type
- protein
- Length
- 10,544 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative mitochondrial dynamin protein
- UniProt
- G0SGC7
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 63% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | Putative mitochondrial dynamin protein | protein | 659 | 63% helix, 7% strand | G0SGC7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 232 | 0.80 | 0.93 | 57 | empty |
| 2 | 237 | 0.80 | 0.93 | 59 | empty |
| 3 | 148 | 0.78 | 0.95 | 48 | empty |
| 4 | 84 | 0.74 | 0.96 | 20 | empty |
| 5 | 97 | 0.74 | 0.95 | 25 | empty |
Interfaces
30 interfaces between chains.
- E–J · 1393 Ų buried · 110 hydrogen bonds · protein-protein
- G–L · 1055 Ų buried · 47 hydrogen bonds · protein-protein
- E–F · 658 Ų buried · 3 hydrogen bonds · protein-protein
- I–J · 658 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 655 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide, 1 isopeptide (disulfide, isopeptide).
Compared structures
- 6RZV · Structure of s-Mgm1 decorating the inner surface of tubulated lipid membranes · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGC7
- Elsewhere: RCSB PDB 6RZV · PDBe 6RZV · UniProt G0SGC7
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