MolNFT v1 · #163331 · protein
Structure of S-MGM1 decorating the outer surface of tubulated lipid membranes
6RZT · Putative mitochondrial dynamin protein: “Structure of S-MGM1 decorating the outer surface of tubulated lipid membranes”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #163331 on GenesisL1: 3D structure, binding…
- PDB
- 6RZT
- Type
- protein
- Length
- 7,908 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative mitochondrial dynamin protein
- UniProt
- G0SGC7
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 64% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Putative mitochondrial dynamin protein | protein | 659 | 64% helix, 7% strand | G0SGC7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.75 | 0.92 | 43 | empty |
| 2 | 889 | 0.74 | 0.78 | 84 | empty |
| 3 | 149 | 0.74 | 0.92 | 41 | empty |
| 4 | 168 | 0.74 | 0.91 | 42 | empty |
| 5 | 91 | 0.74 | 0.95 | 25 | empty |
Interfaces
22 interfaces between chains.
- H–K · 831 Ų buried · 17 hydrogen bonds · protein-protein
- D–I · 788 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 691 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 691 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 688 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 6RZT · Structure of s-Mgm1 decorating the outer surface of tubulated lipid membranes · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGC7
- Elsewhere: RCSB PDB 6RZT · PDBe 6RZT · UniProt G0SGC7
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