MolNFT v1 · #163253 · protein

Edds lyase variant D290M/Y320M with bound formate

6RXA · Argininosuccinate lyase: “Edds lyase variant D290M/Y320M with bound formate”. X-ray diffraction, 1 ligand (NA), 6 pockets (best druggability 0.53). MolNFT v1 #163253 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RXA
Type: protein
Length: 497 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Argininosuccinate lyase
UniProt: Q11KV9
Ligands: NA
Pockets: 6 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Argininosuccinate lyase	protein	497	69% helix, 4% strand	Q11KV9

Ligands and binding sites

NA · Sodium ion · metal · 2 copies · chains A
FMT · Formic acid · additive · 3 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	195	0.53	0.78	22	empty
2	72	0.40	0.79	17	empty
3	88	0.39	0.77	18	empty
4	56	0.32	0.76	16	empty
5	55	0.32	0.77	15	empty

Compared structures

6RXA · EDDS lyase variant D290M/Y320M with bound formate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q11KV9
Elsewhere: RCSB PDB 6RXA · PDBe 6RXA · UniProt Q11KV9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.