MolNFT v1 · #163242 · protein

Structure of zika virus NS3 helicase in complex with ADP-BEF3

6RWZ · Non-structural protein 3: “Structure of zika virus NS3 helicase in complex with ADP-BEF3”. X-ray diffraction, 3 ligands (BEF, ADP, MN), 3 pockets (best druggability 0.81). MolNFT v1 #163242 on GenesisL1: 3D structure, binding sites…

PDB: 6RWZ
Type: protein
Length: 441 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 3
UniProt: A0A160JCU6
Ligands: BEF, ADP, MN
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Non-structural protein 3	protein	441	32% helix, 19% strand	A0A160JCU6

Ligands and binding sites

BEF · Beryllium trifluoride ion · ligand · chains A
ADP · Adenosine-5'-diphosphate · ligand · chains A
MN · Manganese (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1129	0.81	0.82	94	empty
2	143	0.56	0.82	30	MN, BEF, ADP
3	53	0.32	0.77	16	empty

Compared structures

6RWZ · Structure of Zika virus NS3 helicase in complex with ADP-BeF3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A160JCU6
Elsewhere: RCSB PDB 6RWZ · PDBe 6RWZ · UniProt A0A160JCU6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.