MolNFT v1 · #163135 · protein

Hoefavidin P61C mutant generates a stabilized octamer

6RTQ: “Hoefavidin P61C mutant generates a stabilized octamer”. X-ray diffraction, 3 pockets (best druggability 0.49). MolNFT v1 #163135 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RTQ
Type: protein
Length: 266 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hoefavidin
UniProt: A9D857
Pockets: 3 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hoefavidin	protein	133	0% helix, 50% strand	A9D857

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.49	0.79	18	empty
2	118	0.48	0.79	20	empty
3	51	0.32	0.78	22	empty

Interfaces

1 interface between chains.

A–B · 1687 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6RTQ · Hoefavidin P61C mutant generates a stabilized octamer · the same entry in another collection · chain A against A, TM-score 1.00
A9D857 · AlphaFold monomer V2.0 prediction for hoefavidin (A9D857) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9D857
Elsewhere: RCSB PDB 6RTQ · PDBe 6RTQ · UniProt A9D857

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