MolNFT v1 · #162726 · protein
Structure of chloroflexus aggregans CAGG_3753 lov domain C85A variant (cagfbfp)
6RHF · Multi-sensor hybrid histidine kinase: “Structure of chloroflexus aggregans CAGG_3753 lov domain C85A variant (cagfbfp)”. X-ray diffraction, 1 ligand (FMN), 3 pockets (best druggability 0.74). MolNFT v1 #162726 on GenesisL1: 3D…
- PDB
- 6RHF
- Type
- protein
- Length
- 211 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multi-sensor hybrid histidine kinase
- UniProt
- B8GAY9
- Ligands
- FMN
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multi-sensor hybrid histidine kinase | protein | 106 | 25% helix, 38% strand | B8GAY9 |
| B | Multi-sensor hybrid histidine kinase | protein | 105 | 27% helix, 38% strand | B8GAY9 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.74 | 0.91 | 24 | FMN |
| 2 | 161 | 0.72 | 0.90 | 23 | FMN |
| 3 | 124 | 0.43 | 0.77 | 20 | GOL |
Interfaces
1 interface between chains.
- A–B · 748 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6RHF · Structure of Chloroflexus aggregans Cagg_3753 LOV domain C85A variant (CagFbFP) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8GAY9
- Elsewhere: RCSB PDB 6RHF · PDBe 6RHF · UniProt B8GAY9
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