MolNFT v1 · #162704 · protein

Crystal structure of the cofactor-free aspergillus flavus urate oxidase T57A variant anaerobically complexed with 9-methyl uric acid

6RGT · Uricase: “Crystal structure of the cofactor-free aspergillus flavus urate oxidase T57A variant anaerobically complexed…”. X-ray diffraction, 1 ligand (MUA), 2 pockets (best druggability 0.57). MolNFT v1 #162704 on GenesisL1: 3D…

PDB: 6RGT
Type: protein
Length: 301 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uricase
EC: 1.7.3.3
UniProt: Q00511
Ligands: MUA
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uricase (EC 1.7.3.3)	protein	301	27% helix, 38% strand	Q00511

Ligands and binding sites

MUA · 9-methyl uric acid · ligand · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A
MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	221	0.57	0.79	24	empty
2	167	0.47	0.76	20	MUA

Compared structures

6RGT · Crystal structure of the cofactor-free Aspergillus flavus urate oxidase T57A variant… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00511
Elsewhere: RCSB PDB 6RGT · PDBe 6RGT · UniProt Q00511

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