MolNFT v1 · #162655 · protein

Structure of the vaccinia core protein E11

6RFG · 15 kda core protein: “Structure of the vaccinia core protein E11”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #162655 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RFG
Type: protein
Length: 520 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 15 kda core protein
UniProt: Q49PR7
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 4 distinct chains · 11% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	15 kda core protein	protein	135	11% helix, 45% strand	Q49PR7
B	15 kda core protein	protein	129	9% helix, 46% strand	Q49PR7
C	15 kda core protein	protein	133	15% helix, 52% strand	Q49PR7
D	15 kda core protein	protein	123	9% helix, 47% strand	Q49PR7

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	571	0.64	0.75	52	empty
2	70	0.36	0.77	22	empty
3	110	0.35	0.73	20	empty
4	59	0.34	0.77	18	empty
5	57	0.33	0.77	21	empty

Interfaces

3 interfaces between chains.

A–D · 844 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 825 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 361 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6RFG · Structure of the Vaccinia core protein E11 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q49PR7
Elsewhere: RCSB PDB 6RFG · PDBe 6RFG · UniProt Q49PR7

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