MolNFT v1 · #1626 · protein + RNA

Sxl-lethal PROTEIN/RNA complex

1B7F · RNA (5'-R(P*GP*UP*UP*GP*UP*UP*UP*UP*UP*UP*UP*U)-3'): “Sxl-lethal PROTEIN/RNA complex”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #1626 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1B7F
Type: protein + RNA
Length: 358 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(P*GP*UP*UP*GP*UP*UP*UP*UP*UP*UP*UP*U)-3'); Protein (sxl-lethal protein)
UniProt: P19339
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
P, Q	RNA (5'-R(PGPUPUPGPUPUPUPUPUPUPUPU)-3')	rna	12	—	—
A, B	Protein (sxl-lethal protein)	protein	167	23% helix, 32% strand	P19339

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.29	0.73	18	empty
2	52	0.23	0.72	12	empty

Interfaces

3 interfaces between chains.

P–A · 1510 Å² buried · 45 hydrogen bonds · protein-nucleic
Q–B · 1425 Å² buried · 38 hydrogen bonds · protein-nucleic
A–B · 183 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1B7F · Sxl-lethal PROTEIN/RNA complex · the same entry in another collection · chain P against P, TM-score 1.00
P19339 · AlphaFold monomer V2.0 prediction for protein sex-lethal (P19339) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19339
Elsewhere: RCSB PDB 1B7F · PDBe 1B7F · UniProt P19339

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