MolNFT v1 · #162507 · protein

Crystal structure of the vhh-domain of anti-il-17A antibody netakimab

6RBB · Vhh domain of netakimab: “Crystal structure of the vhh-domain of anti-il-17A antibody netakimab”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #162507 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RBB
Type: protein
Length: 483 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vhh domain of netakimab
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Vhh domain of netakimab	protein	123	5% helix, 46% strand	—
I, J, K	Vhh domain of netakimab	protein	120	10% helix, 49% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	767	0.74	0.79	92	empty
2	202	0.45	0.74	30	empty
3	147	0.39	0.73	28	empty

Interfaces

5 interfaces between chains.

H–K · 333 Å² buried · 5 hydrogen bonds · protein-protein
I–J · 311 Å² buried · 2 hydrogen bonds · protein-protein
I–K · 215 Å² buried · 6 hydrogen bonds · protein-protein
H–J · 205 Å² buried · 7 hydrogen bonds · protein-protein
H–I · 83 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6RBB · CRYSTAL STRUCTURE OF the VhH-domain of anti-IL-17A antibody netakimab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6RBB · PDBe 6RBB

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