MolNFT v1 · #162479 · protein
Heterodimeric ABC exporter tmrab in inward-facing narrow conformation under turnover conditions
6RAF · Multidrug resistance ABC transporter ATP-binding and…: “Heterodimeric ABC exporter tmrab in inward-facing narrow conformation under turnover conditions”. Electron microscopy, 3 ligands (ATP, ADP, MG), 19 pockets (best druggability…
- PDB
- 6RAF
- Type
- protein
- Length
- 1,280 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance ABC transporter ATP-binding and permease protein; Anti-vesicular…
- UniProt
- Q72J05, Q72J04, A0A192B6J5
- Ligands
- ATP, ADP, MG
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 60% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 588 | 65% helix, 11% strand | Q72J05 |
| B | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 571 | 67% helix, 11% strand | Q72J04 |
| C | Anti-vesicular stomatitis virus N vhh | protein | 121 | 2% helix, 50% strand | A0A192B6J5 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1115 | 0.84 | 0.85 | 99 | empty |
| 2 | 159 | 0.78 | 0.95 | 27 | empty |
| 3 | 166 | 0.68 | 0.86 | 19 | empty |
| 4 | 363 | 0.61 | 0.78 | 37 | empty |
| 5 | 143 | 0.55 | 0.81 | 23 | empty |
Interfaces
2 interfaces between chains.
- A–B · 6640 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 726 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6RAF · Heterodimeric ABC exporter TmrAB in inward-facing narrow conformation under turnover… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72J05
- Every structure of UniProt Q72J04
- Every structure of UniProt A0A192B6J5
- Elsewhere: RCSB PDB 6RAF · PDBe 6RAF · UniProt Q72J05 · UniProt Q72J04 · UniProt A0A192B6J5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.