MolNFT v1 · #162419 · protein

PP4R3A EVH1 domain bound to fxxp motif

6R8I · SERINE/THREONINE-protein phosphatase 4 regulatory subunit 3A: “PP4R3A EVH1 domain bound to fxxp motif”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #162419 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6R8I
Type: protein
Length: 129 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein phosphatase 4 regulatory subunit 3A…
UniProt: Q6IN85
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein phosphatase 4 regulatory subunit 3A	protein	112	13% helix, 48% strand	Q6IN85
B	Ser-leu-pro-phe-thr-phe-lys-val-pro-ala-pro-pro-pro-ser- leu-pro-pro-ser	protein	17	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.27	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 604 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6R8I · PP4R3A EVH1 domain bound to FxxP motif · the same entry in another collection · chain A against A, TM-score 1.00
Q6IN85 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 4 regulatory… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6IN85
Elsewhere: RCSB PDB 6R8I · PDBe 6R8I · UniProt Q6IN85

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