MolNFT v1 · #162408 · protein

Crystal structure of the tldc domain of SKYWALKER/TBC1D24 from drosophila melanogaster

6R82 · GTPase-activating protein skywalker: “Crystal structure of the tldc domain of SKYWALKER/TBC1D24 from drosophila melanogaster”. X-ray diffraction, 1 pocket (best druggability 0.28). MolNFT v1 #162408 on GenesisL1: 3D structure…

PDB: 6R82
Type: protein
Length: 348 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTPase-activating protein skywalker
UniProt: Q9VIH7
Pockets: 1 · best druggability 0.28

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTPase-activating protein skywalker	protein	181	20% helix, 33% strand	Q9VIH7
B	GTPase-activating protein skywalker	protein	167	17% helix, 35% strand	Q9VIH7

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.28	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 862 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6R82 · Crystal structure of the TLDc domain of Skywalker/TBC1D24 from Drosophila melanogaster · the same entry in another collection · chain A against A, TM-score 1.00
Q9VIH7 · AlphaFold monomer V2.0 prediction for GTPase-activating protein skywalker (Q9VIH7) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VIH7
Elsewhere: RCSB PDB 6R82 · PDBe 6R82 · UniProt Q9VIH7

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