MolNFT v1 · #162342 · protein

9-bladed beta-propeller formed by three 3-bladed fragments

6R5Z: “9-bladed beta-propeller formed by three 3-bladed fragments”. X-ray diffraction, 10 pockets (best druggability 0.61). MolNFT v1 #162342 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6R5Z
Type: protein
Length: 714 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 9-bladed beta-propeller formed by three 3-bladed fragments
Pockets: 10 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	9-bladed beta-propeller formed by three 3-bladed fragments	protein	119	0% helix, 55% strand	—

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	620	0.61	0.73	65	empty
2	631	0.61	0.72	62	empty
3	99	0.45	0.79	17	empty
4	110	0.44	0.78	20	empty
5	88	0.43	0.79	20	empty

Interfaces

7 interfaces between chains.

E–F · 750 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 749 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 717 Å² buried · 4 hydrogen bonds · protein-protein
D–F · 689 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 686 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6R5Z · 9-bladed beta-propeller formed by three 3-bladed fragments · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6R5Z · PDBe 6R5Z

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