MolNFT v1 · #162221 · protein

Crystal structure of the SUN1-KASH5 6:6 complex

6R2I · Sun domain-containing protein 1: “Crystal structure of the SUN1-KASH5 6:6 complex”. X-ray diffraction, 1 ligand (K), 1 pocket (best druggability 0.47). MolNFT v1 #162221 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6R2I
Type: protein
Length: 217 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sun domain-containing protein 1; KASH5
UniProt: O94901
Ligands: K
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 14% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sun domain-containing protein 1	protein	198	15% helix, 39% strand	O94901
B	KASH5	protein	19	0% helix, 5% strand	—

Ligands and binding sites

K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	177	0.47	0.76	26	empty

Interfaces

1 interface between chains.

A–B · 759 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6R2I · Crystal structure of the SUN1-KASH5 6:6 complex · the same entry in another collection · chain A against A, TM-score 1.00
O94901 · AlphaFold monomer V2.0 prediction for sun domain-containing protein 1 (O94901) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94901
Elsewhere: RCSB PDB 6R2I · PDBe 6R2I · UniProt O94901

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