MolNFT v1 · #162060 · protein + RNA
Influenza a virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' crna promoter and NB8205
6QXE: “Influenza a virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' crna promoter and…”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #162060 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6QXE
- Type
- protein + RNA
- Length
- 2,650 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NB8205; Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit…
- EC
- 3.1.-.-, 2.7.7.48
- UniProt
- P03434, P03432, P03429
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M, O | NB8205 | protein | 121 | 5% helix, 41% strand | — |
| A, E | Polymerase acidic protein (EC 3.1.-.-) | protein | 514 | 42% helix, 13% strand | P03434 |
| B, F | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 611 | 43% helix, 9% strand | P03432 |
| C, G | Polymerase basic protein 2 | protein | 67 | 37% helix, 15% strand | P03429 |
| D, H | RNA (5'-R(P*AP*GP*CP*AP*AP*AP*AP*GP*CP*AP*GP*G)-3') | rna | 12 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.82 | 0.96 | 54 | empty |
| 2 | 194 | 0.82 | 0.96 | 52 | empty |
| 3 | 408 | 0.82 | 0.90 | 50 | empty |
| 4 | 310 | 0.78 | 0.89 | 36 | empty |
| 5 | 306 | 0.78 | 0.89 | 36 | empty |
Interfaces
20 interfaces between chains.
- A–B · 7686 Ų buried · 90 hydrogen bonds · protein-protein
- E–F · 7681 Ų buried · 86 hydrogen bonds · protein-protein
- F–G · 1850 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 1841 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1480 Ų buried · 28 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6QXE · Influenza A virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5'… · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03434
- Every structure of UniProt P03432
- Every structure of UniProt P03429
- Elsewhere: RCSB PDB 6QXE · PDBe 6QXE · UniProt P03434 · UniProt P03432 · UniProt P03429
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