MolNFT v1 · #161986 · protein

Crystal structure of the SKI2 RNA-helicase BRR2 from chaetomium thermophilum bound to ATP-gamma-S

6QV4 · Pre-mRNA splicing helicase-like protein: “Crystal structure of the SKI2 RNA-helicase BRR2 from chaetomium thermophilum bound to ATP-gamma-S”. X-ray diffraction, 2 ligands (AGS, MN), 20 pockets (best druggability 0.85). MolNFT v1…

PDB: 6QV4
Type: protein
Length: 1,666 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA splicing helicase-like protein
UniProt: G0S0B9
Ligands: AGS, MN
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA splicing helicase-like protein	protein	1666	45% helix, 15% strand	G0S0B9

Ligands and binding sites

AGS · Phosphothiophosphoric acid-adenylate ester · ligand · 3 copies · chains A
MN · Manganese (II) ion · metal · 3 copies · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	725	0.85	0.88	69	AGS
2	741	0.81	0.84	63	empty
3	305	0.72	0.85	33	empty
4	590	0.71	0.79	61	MN, AGS
5	522	0.71	0.80	46	empty

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S0B9
Elsewhere: RCSB PDB 6QV4 · PDBe 6QV4 · UniProt G0S0B9

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