MolNFT v1 · #161985 · protein

Crystal structure of the SKI2 RNA-helicase BRR2 from chaetomium thermophilum bound to ADP

6QV3 · Pre-mRNA splicing helicase-like protein: “Crystal structure of the SKI2 RNA-helicase BRR2 from chaetomium thermophilum bound to ADP”. X-ray diffraction, 2 ligands (ADP, MN), 20 pockets (best druggability 0.85). MolNFT v1 #161985 on…

PDB: 6QV3
Type: protein
Length: 1,657 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA splicing helicase-like protein
UniProt: G0S0B9
Ligands: ADP, MN
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA splicing helicase-like protein	protein	1657	45% helix, 16% strand	G0S0B9

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 3 copies · chains A
MN · Manganese (II) ion · metal · 2 copies · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1153	0.85	0.86	95	ADP
2	790	0.81	0.84	67	empty
3	377	0.72	0.83	36	empty
4	510	0.69	0.79	49	ADP, MN
5	182	0.68	0.87	23	empty

Compared structures

6QV3 · Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ADP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S0B9
Elsewhere: RCSB PDB 6QV3 · PDBe 6QV3 · UniProt G0S0B9

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