MolNFT v1 · #161837 · protein

Crystal structure of porphyromonas gingivalis glutaminyl cyclase

6QQL · Glutamine cyclotransferase: “Crystal structure of porphyromonas gingivalis glutaminyl cyclase”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.52). MolNFT v1 #161837 on GenesisL1: 3D structure, binding sites and…

PDB: 6QQL
Type: protein
Length: 577 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamine cyclotransferase
UniProt: Q7MT37
Ligands: ZN
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamine cyclotransferase	protein	289	39% helix, 20% strand	Q7MT37
B	Glutamine cyclotransferase	protein	288	39% helix, 20% strand	Q7MT37

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.52	0.81	20	empty
2	119	0.52	0.82	23	empty
3	195	0.47	0.75	37	empty
4	103	0.40	0.77	22	empty
5	121	0.38	0.74	26	empty

Interfaces

1 interface between chains.

A–B · 636 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6QQL · Crystal structure of Porphyromonas gingivalis glutaminyl cyclase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7MT37
Elsewhere: RCSB PDB 6QQL · PDBe 6QQL · UniProt Q7MT37

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