MolNFT v1 · #161742 · protein

Influenza a polymerase heterotrimer human H3N2 northern territory 1968

6QNW · Polymerase acidic protein: “Influenza a polymerase heterotrimer human H3N2 northern territory 1968”. X-ray diffraction, 20 pockets (best druggability 0.85). MolNFT v1 #161742 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6QNW
Type: protein
Length: 8,365 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
EC: 3.1.-.-, 2.7.7.48
UniProt: Q1AR05, P03432, P03429
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 12 distinct chains · 39% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase acidic protein (EC 3.1.-.-)	protein	704	38% helix, 15% strand	Q1AR05
B	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	679	44% helix, 11% strand	P03432
C	Polymerase basic protein 2	protein	724	35% helix, 20% strand	P03429
D	Polymerase acidic protein (EC 3.1.-.-)	protein	686	40% helix, 15% strand	Q1AR05
E	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	665	46% helix, 10% strand	P03432
F	Polymerase basic protein 2	protein	720	34% helix, 19% strand	P03429
G	Polymerase acidic protein (EC 3.1.-.-)	protein	701	39% helix, 16% strand	Q1AR05
H	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	676	45% helix, 10% strand	P03432
I	Polymerase basic protein 2	protein	726	34% helix, 19% strand	P03429
J	Polymerase acidic protein (EC 3.1.-.-)	protein	702	39% helix, 15% strand	Q1AR05
K	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	673	45% helix, 10% strand	P03432
L	Polymerase basic protein 2	protein	709	36% helix, 18% strand	P03429

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	812	0.85	0.88	89	empty
2	740	0.82	0.85	83	empty
3	656	0.82	0.86	70	empty
4	1037	0.81	0.82	117	empty
5	1083	0.81	0.82	92	empty

Interfaces

24 interfaces between chains.

A–B · 8298 Å² buried · 100 hydrogen bonds · protein-protein
J–K · 7961 Å² buried · 103 hydrogen bonds · protein-protein
G–H · 7936 Å² buried · 104 hydrogen bonds · protein-protein
D–E · 7799 Å² buried · 88 hydrogen bonds · protein-protein
H–I · 7637 Å² buried · 74 hydrogen bonds · protein-protein

Compared structures

6QNW · Influenza A Polymerase Heterotrimer Human H3N2 Northern Territory 1968 · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1AR05
Every structure of UniProt P03432
Every structure of UniProt P03429
Elsewhere: RCSB PDB 6QNW · PDBe 6QNW · UniProt Q1AR05 · UniProt P03432 · UniProt P03429

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