MolNFT v1 · #161723 · protein
Structure of bovine anti-rsv hybrid Fab B13HC-B4LC
6QNA · B13 heavy chain: “Structure of bovine anti-rsv hybrid Fab B13HC-B4LC”. X-ray diffraction, 20 pockets (best druggability 0.74). MolNFT v1 #161723 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QNA
- Type
- protein
- Length
- 1,760 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B13 heavy chain; B4 light chain
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 5 distinct chains · 5% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | B13 heavy chain | protein | 232 | 5% helix, 52% strand | — |
| L, B, D, F | B4 light chain | protein | 211 | 6% helix, 51% strand | — |
| A | B13 heavy chain | protein | 229 | 5% helix, 52% strand | — |
| C | B13 heavy chain | protein | 227 | 5% helix, 53% strand | — |
| E | B13 heavy chain | protein | 228 | 5% helix, 52% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 849 | 0.74 | 0.78 | 85 | empty |
| 2 | 825 | 0.71 | 0.77 | 89 | empty |
| 3 | 570 | 0.61 | 0.74 | 67 | empty |
| 4 | 127 | 0.60 | 0.85 | 26 | empty |
| 5 | 335 | 0.58 | 0.77 | 43 | empty |
Interfaces
11 interfaces between chains.
- H–L · 2065 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2032 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 2009 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 2008 Ų buried · 13 hydrogen bonds · protein-protein
- L–F · 490 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 28 disulfide (disulfide).
Compared structures
- 6QNA · Structure of bovine anti-RSV hybrid Fab B13HC-B4LC · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6QNA · PDBe 6QNA
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.