MolNFT v1 · #161720 · protein

Structure of bovine anti-rsv hybrid Fab B4HC-B13LC

6QN7 · Heavy chain of bovine anti-rsv B4: “Structure of bovine anti-rsv hybrid Fab B4HC-B13LC”. X-ray diffraction, 7 pockets (best druggability 0.68). MolNFT v1 #161720 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6QN7
Type: protein
Length: 870 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain of bovine anti-rsv B4; Light chain of bovine anti-rsv B13
Pockets: 7 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Heavy chain of bovine anti-rsv B4	protein	223	8% helix, 51% strand	—
L, B	Light chain of bovine anti-rsv B13	protein	213	8% helix, 50% strand	—
A	Heavy chain of bovine anti-rsv B4	protein	221	8% helix, 51% strand	—

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	793	0.68	0.76	82	empty
2	750	0.67	0.75	65	empty
3	87	0.36	0.76	20	empty
4	89	0.34	0.75	18	empty
5	79	0.34	0.75	16	empty

Interfaces

3 interfaces between chains.

A–B · 1917 Å² buried · 14 hydrogen bonds · protein-protein
H–L · 1869 Å² buried · 14 hydrogen bonds · protein-protein
H–A · 234 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

6QN7 · Structure of bovine anti-RSV hybrid Fab B4HC-B13LC · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6QN7 · PDBe 6QN7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.