MolNFT v1 · #161654 · protein
Crystal structure of nucleotide-free MGM1
6QL4 · Putative mitochondrial dynamin protein: “Crystal structure of nucleotide-free MGM1”. X-ray diffraction, 15 pockets (best druggability 0.77). MolNFT v1 #161654 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QL4
- Type
- protein
- Length
- 1,320 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative mitochondrial dynamin protein
- UniProt
- G0SGC7
- Pockets
- 15 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative mitochondrial dynamin protein | protein | 660 | 63% helix, 7% strand | G0SGC7 |
| B | Putative mitochondrial dynamin protein | protein | 660 | 64% helix, 7% strand | G0SGC7 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.77 | 0.96 | 33 | empty |
| 2 | 168 | 0.72 | 0.90 | 36 | empty |
| 3 | 54 | 0.70 | 0.97 | 21 | empty |
| 4 | 91 | 0.68 | 0.92 | 33 | empty |
| 5 | 231 | 0.54 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 635 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 6QL4 · Crystal structure of nucleotide-free Mgm1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGC7
- Elsewhere: RCSB PDB 6QL4 · PDBe 6QL4 · UniProt G0SGC7
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